NER Factor
|
Subunits
|
Function
|
XPC
|
XPC, HR23B
|
Damage Recognition
Molecular Matchmaker
|
TFIIH
|
XPB, XPD, p34, p44, p62, p52, Mat1, Cdk7, Cyclin
H
|
DNA unwinding, Helicase
3¢-5¢ helicase, 5¢-3¢ helicase
|
XPA
|
XPA
|
Damage Recognition
|
RPA
|
RPA70, RPA 32, RPA 14
|
Damage Recognition
DNA Re-synthesis
|
XPG
|
XPG
|
3¢ incision
|
ERCC1-XPF
|
ERCC1, XPF
|
5¢ incision
|
Monday, May 26, 2014
XP associated Genes and their Roles in NER
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