Monday, May 26, 2014

XP associated Genes and their Roles in NER


NER Factor
Subunits
Function
XPC
XPC, HR23B
Damage Recognition
Molecular Matchmaker
TFIIH
XPB, XPD, p34, p44, p62, p52, Mat1, Cdk7, Cyclin H
DNA unwinding, Helicase
3¢-5¢ helicase, 5¢-3¢ helicase
XPA
XPA
Damage Recognition
RPA
RPA70, RPA 32, RPA 14
Damage Recognition
DNA Re-synthesis
XPG
XPG
3¢ incision
ERCC1-XPF
ERCC1, XPF
5¢ incision






Post a Comment