Tuesday, May 20, 2014

Neucleotide Excision Repair !!! ... (1/4)

From the beginning of life, DNA stores the genetic information but has faced a fundamental problem of not being chemically inert. DNA damaged occurs constantly because of

E Chemicals (i.e. intercalating agents)
E Radiation
E Other Mutagen

To protect this ‘Achilles heel’ (a deadly weakness in spite of overall strength), an intricate network of DNA Repair System has evolved early in the evolution, comprising of three excision repair pathways to repair single stranded DNA damage:

E Neucleotide Excision Repair (NER)
E Base Excision Repair (BER)
E DNA mismatch Repair (MMR)

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