Wednesday, May 7, 2014

Types of Xeroderma Pigmentosum

There are 8 inherited forms of Xeroderma Pigmentosum (XP) have been identified ¾ Group (XP-A) to Group G (XP-G) plus one variant type (XP-V).

The types are distinguished by their genetic cause. All of the types are prone to skin cancer although some are more likely than others to be associated with neurological abnormalities.

Type
Disease Database
OMIM
Gene
Locus
Type A I (XP-A)
29877
27800
XPA
9q22.3
Type B II (XP-B)
29878
133510
XPB
2q21
Type C III (XP-C)
29879
278720
XPC
3p25
Type D IV (XP-D)
29880
278730
278800
XPD
ERCC6
19q13.2-q13.3
10q11
Type E V (XP-E)
29881
278740
DDB2
11p12-p11
Type F VI (XP-F)
29882
278760
ERCC4
16p13.3-p13.13
Type G VII (XP-G)
29883
278780
133530
RAD2
ERCC5
13q33
Type V VIII (XP-V)

278750
POLH
6p21.1-p12



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