Types of Xeroderma Pigmentosum

There are 8 inherited forms of Xeroderma Pigmentosum (XP) have been identified ¾ Group (XP-A) to Group G (XP-G) plus one variant type (XP-V).

The types are distinguished by their genetic cause. All of the types are prone to skin cancer although some are more likely than others to be associated with neurological abnormalities.

Type	Disease Database	OMIM	Gene	Locus
Type A I (XP-A)	29877	27800	XPA	9q22.3
Type B II (XP-B)	29878	133510	XPB	2q21
Type C III (XP-C)	29879	278720	XPC	3p25
Type D IV (XP-D)	29880	278730 278800	XPD ERCC6	19q13.2-q13.3 10q11
Type E V (XP-E)	29881	278740	DDB2	11p12-p11
Type F VI (XP-F)	29882	278760	ERCC4	16p13.3-p13.13
Type G VII (XP-G)	29883	278780 133530	RAD2 ERCC5	13q33
Type V VIII (XP-V)		278750	POLH	6p21.1-p12