Keratin Filaments
Keratins 5 and 14 combine to form
intermediate filaments in basal keratinocytes. Keratins contain a central
alpha-helical rod with several nonhelical interruptions, as well as nonhelical
carboxyterminal and aminoterminal regions. The regions of highest conservation
between the keratins are located on the ends of the keratin rod in the helix
boundary motifs. Keratin intermediate filaments insert upon electron-dense
structures termed hemidesmosomes.
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