Hemidesmosomes
The structure of ‘Hemidesmosomes’ contain intracellular
proteins including ‘plectin’ and ‘BP230’.
Plectin (HD1) is a 500-kd protein which
binds intermediate filaments.
BP230 (also termed as BPAG1) is a 230-kd
protein which has homology to both desmoplakin
and plectin. BP230, like plectin,
functions in the connection between ‘hemidesmosomes’
and ‘intermediate filaments’.
Hemidesmosomes also contain the
intracellular portions of the transmembrane proteins collagen XVII (BP180) and
alpha-6-beta-4 (α-6-β-4) integrin. The β-4 integrin subunit performs a central role in hemidesmosome
formation and contains an especially large cytoplasmic domain, which interacts
with other proteins of the hemidesmosomal plaque. Collagen XVII is a
transmembrane collagenous protein which interacts with α-4 integrin and BP230 intracellularly and with laminin 5
extracellularly.
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