Frequency...

United States

Assuming that mild cases of Epidermolysis Bullosa simplex are reported only 10% of the time; the affected population in the United States is approximately 12,500 persons. According to a National Epidermolysis Bullosa Registry report, 50 Epidermolysis Bullosa cases occur per 1 million live births. Of these cases, approximately 92% are Epidermolysis Bullosa Simplex [EBS], 5% are Dystrophic Epidermolysis Bullosa [DEB], 1% is Junctional Epidermolysis Bullosa [JEB], and 2% are unclassified. Patients with Hemidesmosomal Epidermolysis Bullosa probably constitute much less than 1% of total Epidermolysis Bullosa cases.

International

As per the National Epidermolysis Bullosa Registry, the number of Epidermolysis Bullosa cases in Norway is 54 cases per million live births, in Japan 7.8 cases per million live births and in Croatia is 9.6 cases per million live births.