Skin is a
pretty amazing organ. It’s gone through a continuous regeneration procedure
where new skin cells (keratinocyte) are born and replace
the dead cells that slough off. Before the dead skin cells peels off, they
actually serve as the barrier which protects the younger skin and internal
organs beneath from exposure to the elements, radiation from the sun and
infection from bacteria.
Human skin
also has a defense system which goes to work when its integrity gets
compromised by injuries from friction or heat. We can see this system in action
every time a blister forms on our skin.
When skin
is irritated by friction or exposure to high temperatures, the layers can loosen.
When this occurs, the empty pocket between the two layers~ ‘epidermis’
& ‘dermis’ [‘Epidermis’ is the outer layer while ‘Dermis’ is the underlying
layer] ~ is filled with a fluid called ‘serum’.
This serum serves as a cushion that allows the immature, tender skin beneath to
heal, a process called re-epithelialization. When it is
done, the injured outside layer deadens and falls off.
‘Blister’ is a
normal and beneficial reaction to damaged skin. For most of us, they pose
little more than a nuisance. But for people who suffer from a condition called Epidermolysis
Bullosa (EB), the blisters can be life-threatening.
Epidermolysis
Bullosa (EB) is a inherited disorder where mutations on 10 genes lead to a
heightened blister response in the sufferer's skin. People who suffers with EB
have fragile skin; mild heat and friction can create injuries and cause
blisters. While blisters can be painful, consistent and prolonged blistering
can also pose a risk to a person's health, as it increases the likelihood that
a blister will become infected. [NIAMS]
‘Butterfly
children’ is a term often used to describe younger patients—because, the skin
is said to be as fragile as a butterfly’s wing. The severe pain hardly allows
patients with Epidermolysis Bullosa (EB) to live
a normal life. It is even difficult for the patients to walk because the stress
on the soles of the feet causes stabbing pain.
Source: www.howstuffworks.com
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