Monday, March 4, 2013

LAMA3 gene....Function

Function of the LAMA3 gene

The LAMA3 gene provides instructions for making one protein subunit — laminin 332 (formerly known as laminin 5). Laminin 332 is made up of 3 subunits — called alpha (α), beta (β) and gamma (g). The LAMB3 gene carries instructions for the beta (β) subunit; the alpha (α) and gamma (g) subunits are produced from other genes.

Laminins are a group of proteins which regulate cell growth, cell movement (motility) and the attachment of cells to one another (adhesion). They are also involved in the formation and organization of basement membranes — which are thin, sheet-like structures — separate and support cells in many tissues. 

Laminin 332 has an important role in the basement membrane which underlies the top layer of skin (the epidermis). As we discussed earlier basement membrane gives strength & resiliency to the skin and creates an additional barrier between the body and its surrounding environment. 

Laminin 332 is a major component of anchoring filaments which connect the two layers of the basement membrane and help hold the skin together.

Studies suggest that laminin 332 also has several other functions. This protein appears to be important for wound healing. Additionally, researchers have proposed roles for laminin 332 in the clear outer covering of the eye (the cornea) and in the development of tooth enamel.


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