Anchoring filaments
These structures contain the
extracellular portions of collagen XVII (BP180) and alpha-6-beta-4 (α-6-β-4) integrin. In addition, anchoring
filaments contain the molecules ‘laminin
5’ and ‘laminin 6’. Similar to
all members of the family of laminin proteins, laminin 5 is a large
heterotrimeric molecule, containing α-3, β-3, and g-2
chains. Laminin 5 forms a disulfide-bonded attachment to laminin 6, the other
known anchoring filament laminin, which contains α-3, β-1, and g-1
chains. Laminin 5 also forms a strong association with type VII collagen, which
serves to connect anchoring filaments with anchoring fibrils.
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