Tuesday, June 25, 2013

PLOD1 Gene … Normal Function

The PLOD1 gene provides instructions for making an enzyme called ‘lysyl hydroxylase 1 which modifies a particular amino acid called ‘lysine’, one of the building blocks used to make proteins. Specifically, ‘lysyl hydroxylase 1’ adds a single oxygen atom to a hydrogen atom to create a charged molecule called a ‘hydroxyl group’. Hydroxyl groups attach to some of the ‘lysines’ in collagen-like proteins. We already know that ‘Collagens’ are complex molecules which provide strength, support and elasticity (the ability to stretch) to many body tissues.

‘Hydroxyl groups’ are essential for collagen molecules to form stable interactions called cross-links with one another. Cross-links between these molecules allow collagen to form networks of strong, slender fibrils, which are an important part of the normal structure of connective tissue which binds and supports the body's muscles, ligaments, organs, and skin.

Post a Comment