We already discussed about the ‘Collagen Protein’ in our COL5A1 gene discussion.
The COL5A2 gene produces a component of type V collagen, called the pro-alpha2 (V) chain. 1 pro-alpha2 (V) chain combines with 2 pro-alpha1 (V) chains (produced by the COL5A1 gene) to form ‘Type V pro-collagen’.
These triple-stranded, rope-like pro-collagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong, mature type V collagen fibers.
As we discussed earlier ‘Type V collagen’ also plays a role in assembling other types of collagen into fibrils within many connective tissues.