Wednesday, January 7, 2015

Inheritance .....

Most of the cases Cutis Laxa is inherited. There generally 3 types of forms of genetic inheritance…

E Sex Linked
E Autosomal Dominant
E Autosomal Recessive

The Autosomal Recessive form is the most common & severe.


Sex-linked
The defective/mutated gene is carried on one of the sex chromosomes, in this case it is located on the X chromosome
Autosomal Dominant
Only one copy of the defective/mutated gene is enough to cause CL. A child has a 50% chance of inheriting the gene from either parent.
Autosomal Recessive
In this type the affected child must inherit two copies of the defective/mutated gene from both of its parent. The chance of transmitting an autosomal recessive disease is 25% for each pregnancy.


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