Tuesday, April 8, 2014

HISTORY ..... (2/2)

In 1932, de Sanctis and Cacchione described three brothers in the same family with features of XP, mental deficiency, dwarfism, and gonadal hypoplasia with progressive neurological degeneration beginning at 2 years of age (de Sanctis and Cacchione, 1932). This severe phenotype is not commonly observed.

XP was described in a black African in 1938 (Loewenthal and Trowell, 1938; Figure 1c) and in an American black in 1940 (King and Hamilton, 1940).

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