The ADAMTS2 gene provides
instructions for making an enzyme that processes several types of ‘pro-collagen
molecules’. We already discussed that ‘Procollagens’ are the precursors of
collagens — which are complex molecules that add strength,
support and elasticity (the ability to stretch) to many body tissues.
Specifically, the ADAMTS2 enzyme clips a short
chain of protein building blocks (amino acids) of one end of procollagens. This
clipping step is necessary for the collagen molecules to assemble into strong,
slender fibrils outside cells.
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