Wednesday, July 31, 2013

ADAMTS2 Gene … Normal Function

The ADAMTS2 gene provides instructions for making an enzyme that processes several types of ‘pro-collagen molecules’. We already discussed that ‘Procollagens’ are the precursors of collagens which are complex molecules that add strength, support and elasticity (the ability to stretch) to many body tissues.

Specifically, the ADAMTS2 enzyme clips a short chain of protein building blocks (amino acids) of one end of procollagens. This clipping step is necessary for the collagen molecules to assemble into strong, slender fibrils outside cells.




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