Function of the KRT5 gene...
The KRT5 gene provides instructions for making a protein called keratin 5.
Keratins are a group of tough, fibrous proteins which form the structural framework for the cells which make up the skin, hair, and nails. Keratin 5 is produced in cells called keratinocytes found in the outer layer of the skin (the epidermis).
Keratin 5 partners with a similar protein, keratin 14, to form molecules called keratin intermediate filaments. These filaments assemble into strong networks which help keratinocytes to attach together and anchor the epidermis to underlying layers of skin. The network of keratin intermediate filaments provides strength and resilience to the skin and protects it from being damaged by friction and other everyday physical stresses.
Researchers also believe that keratin 5 may also play a role in transporting ‘melanosomes’, which are cellular structures that produce a pigment called melanin. The transport of these structures into keratinocytes is important for normal skin coloration (pigmentation).