In 1932, de Sanctis and Cacchione described three brothers
in the same family with features of XP, mental deficiency, dwarfism, and
gonadal hypoplasia with progressive neurological degeneration beginning at 2
years of age (de Sanctis and Cacchione,
1932). This severe phenotype is not commonly observed.
XP was described in a black African in 1938 (Loewenthal and Trowell, 1938; Figure 1c)
and in an American black in 1940 (King
and Hamilton, 1940).
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