From the beginning of
life, DNA stores the genetic information but has faced a fundamental problem of
not being chemically inert. DNA damaged occurs constantly because of
E
Chemicals
(i.e. intercalating agents)
E
Radiation
E
Other Mutagen
To protect this ‘Achilles
heel’ (a deadly weakness in spite of overall strength), an intricate network of
DNA Repair System has evolved early in the evolution, comprising of three
excision repair pathways to repair single stranded DNA damage:
E
Neucleotide
Excision Repair (NER)
E
Base Excision
Repair (BER)
E
DNA mismatch
Repair (MMR)
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