Function
of the KRT5 gene...
The KRT5 gene
provides instructions for making a protein called keratin 5.
Keratins
are a group of tough, fibrous proteins which form the structural framework for the
cells which make up the skin, hair, and nails. Keratin 5 is produced in cells
called keratinocytes found in the outer layer of the skin (the epidermis).
Keratin
5 partners with a similar protein, keratin 14, to form molecules called keratin
intermediate filaments. These filaments assemble into strong networks which
help keratinocytes to attach together and anchor the epidermis to underlying
layers of skin. The network of keratin intermediate filaments provides strength
and resilience to the skin and protects it from being damaged by friction and
other everyday physical stresses.
Researchers
also believe that keratin 5 may also play a role in transporting ‘melanosomes’,
which are cellular structures that produce a pigment called melanin. The
transport of these structures into keratinocytes is important for normal skin
coloration (pigmentation).
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